Dictionary of Human Evolution and Biology

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ABO Incompatibility

Lowered probability of conception owing to the genotypes in the ABO blood group possessed by potential parents. In populations that maintain all three alleles, it has been suggested that type O mothers produce fewer offspring than expected when the fathers are either type A or type B; this may be due to the presence of either antibodies in the mother’s vaginal secretions (that could agglutinate sperm), or certain smaller classes of maternal anti-A and anti-B antibodies that could pass through the placenta and affect the development of the fetus.

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