Dictionary of Human Evolution and Biology

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Bloom Syndrome

Autosomal recessive pre-and post-natal growth deficiency characterized by dwarfism, sun sensitivity that results in skin rashes, dilated capillaries, impaired immunity, increased risk of cancer, and chromosomal instability. Death before age 50; usually much sooner. A DNA excisionrepair disorder in which a DNA ligase gene is defective and slows DNA replication. Exhibits evidence for somatic recombination.

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