Dictionary of Human Evolution and Biology

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Bombay Phenotype

Rare but informative variant of the ABO blood group in which affected individuals cannot make the H substance precursor protein needed by the A and B antigens and the null O allele; individuals with this phenotype are homozygous recessive (hh) but appear to be blood type O. They also make a unique anti-H antibody. First discovered in Bombay, India. A classic case of epistasis. Aka Bombay blood group.

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