Dictionary of Human Evolution and Biology

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Charcot-Marie-Tooth Disease (CMT)

Set of related conditions characterized by progressive los of feeling in arms and legs, and progressive limb atrophy; CMT is caused by mutations in a peripheral myelin protein gene (PMP22). CMT is heterogenous; there is an autosomal dominant (CMT 1), an autosomal recessive, and an X-linked form (CMTD2), each of which has several types and subtypes. CMT is also associated with a similar condition, Dejerine Sottas syndrome (DSS). CMT is the most common inherited peripheral neuropathy, and is found worldwide.

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