Dictionary of Human Evolution and Biology

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CpG Doublet

Adjacent sequence of cytosine and guanine nucleotides along a sugar-phosphate backbone, reading from the 5 toward the 3 end of DNA. A series of such doublets is called a CpG island; because of the base pairing rule, the islands form a short palindrome and are often sites of DNA methylation (at cytocine): 5...CpG CpG...3 3...GpC GpC...5.

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