Dictionary of Human Evolution and Biology

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Diego Blood Group

The Diego blood group antibodies, anti-Di(a) and anti-Di(b), are familial or low-incidence antigens that can result in hemolytic disease of the newborn. The antigens were discovered in a South American family in 1953 and are mutational variants of the SLC4A1 gene. This so-called Mongoloid marker is useful in population studies as it enables researchers to track the emigration of peoples from the Mammoth Steppe between the Tibetan Plateau and Mongolia to modern destinations in India, New Guinea, Kamchatka, and into the Americas as far south as Chile.

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