Heritable,
autosomal dominant neurodegenerative condition characterized by tremors, muscular stiffness, and walking and balance difficulties; Lewy bodies are inclusional in many regions of the
brain.
Mutations in
alpha synuclein (SNCA) cause fragmentation; SNCA fragments are characteristic of some
forms of both PD1 and
Alzheimer disease. Not all
forms of PD are inherited.