Dictionary of Human Evolution and Biology

Dictionary of Human Evolution and Biology

Parkinson Disease, Familial

Heritable, autosomal dominant neurodegenerative condition characterized by tremors, muscular stiffness, and walking and balance difficulties; Lewy bodies are inclusional in many regions of the brain. Mutations in alpha synuclein (SNCA) cause fragmentation; SNCA fragments are characteristic of some forms of both PD1 and Alzheimer disease. Not all forms of PD are inherited.

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Alzheimer disease (... ’s dementia, presenile dementia. Cf. Parkinson disease.)
genetic disease (... direct fitness. Aka hereditary disease, familial disease.)
Creutzfeldt-Jakob disease, new variant (... protein. See Creutzfeldt-Jakob disease, familial, and Creutzfeldt-Jakob disease, sporadic.)
essential tremor (... and less debilitating than familial Parkinson disease.)
neurological disorder (... , Huntington disease, Parkinson disease, amyotrophic lateral sclerosis and Tay-Sachs disease.)