Dictionary of Human Evolution and Biology

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Rhesus Isoimmunization

Coincidental condition characterized by los of fetal RBCs owing to the agglutination in utero by maternal anti-D antibodies, causing jaundice, anemia, hypoxia with CNS damage, and an enlarged liver and spleen in the affected fetus. Isoimmunization also occurs in several other blood groups, including the ABO, Diego, Duffy, Kell- Cellano and Gerbich blood groups, but Rh incompatibility accounts for more than 90% of cases.

See hemolytic disease of the newborn.

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