Dictionary of Human Evolution and Biology

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Werner Syndrome

One of the progerias, or autosomal recessive syndromes in which the rate of aging is increased, or at least mimicked. In WRN, onset is in the second or third decade of life; by age 40 an affected individual has premature wrinkles, baldness, cataracts, muscular dystrophy, and diabetes. Lifespan is truncated. The defective gene is WRN, probably a helicase in the RecQ family that normally unwinds dsDNA.

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