Dictionary of Human Evolution and Biology

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Adenomatous Polyposis Of The Colon, Familial

One of the two most common forms of hereditary colorectal cancer. FAP is an autosomal dominant found in adolescents who present with abdominal pain, diarrhea and rectal bleeding. A carpet of pre-cancerous growths, usually in the colon, progresses to colorectal cancer. The mutant gene is adenomatous polyposis coli (APC); about 740 different mutations in this gene have been identified with simultaneous loss of heterozygosity or mutation to the p53 tumor suppressor gene. There is some evidence for a paternal age effect. Aka familial polyposis of the colon (FPC).

Cf. colon cancer, hereditary nonpolyposis.

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