Dictionary of Human Evolution and Biology

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Adult Hemoglobin

Umbrella term for three forms of hemoglobin found in the erythrocytes of adult humans that are metabolically active in the late fetal stages of development through adulthood. The majority consists of hemoglobin A (aka the major fraction) and about 2% is hemoglobin A2, the minor fraction; a very small percentage consists of the so-called fetal fraction, which, however, is not quite identical to fetal hemoglobin in that the fraction circulating in normal adults has an amino acid substitution at position 136 in the chain compared with the normal fetal form.

Cf. embryonic hemoglobin.

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