Dictionary of Human Evolution and Biology

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Amyloidosis, Type I

Autosomal dominant condition characterized by cerebral hemorrhaging in older adults, and featuring build-up of a fibrillized, gummy protein, amyloid, owing to mutations that cause misfolding in transthyretin (TTR). One of at least seven varieties of amyloidosis (the TTR amyloid diseases); most are related to specific mutations in the TTR protein. Aka familial amyloid neuropathy (FAP), Dutch variety amyloidosis.

See protein misfolding disorder.

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