Dictionary of Human Evolution and Biology

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Chromosomal Sex

Determination of gender. In mammals, the male is usually the heterogametic sex (XY) and the female the homogametic sex (XX). Thus, males carry the sex-determining chromosome, which is actually a gene or a few genes (e.g. TDF gene or SRY gene) usually located on the Y chromosome. The SRY gene can rarely become translocated to its segregation partner, the X chromosome. For this reason, some rare XX individuals can be phenotypic males in future generations.

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