Dictionary of Human Evolution and Biology

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Colon Cancer, Hereditary Nonpolyposis

Cancer caused by mutations that occur in DNA repair genes. There are two major varieties, type I and type II. In type I colorectal cancer, the affected gene is MLN1, an autosomal dominant (aka familial colon cancer, type 1, FCC1). Type II, also an autosomal dominant, is caused by multiple mutations in genes at up to 13 loci. Loss of heterozygosity is a feature at these loci. Aka colorectal cancer (CRC), familial colon cancer type 2 (FCC2).

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