Dictionary of Human Evolution and Biology

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Ectodermal Dysplasia, Anhidrotic Type

Affected males have hypertrichosis, abnormal or missing teeth, and absence of sweat glands (with hypohidrosis). The EDA gene is an X-linked recessive. Heterozygous female carriers show milder symptoms. Affects thermoregulation; the condition tends to cluster, e.g. the Whitaker Negroes of Mississippi or the toothless men of Sind (Hyderabad, India); the latter were mentioned by Darwin in 1875. Aka hypohidrotic type ED.

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