Dictionary of Human Evolution and Biology

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Error Catastrophe Theory Of Aging

Intracellular, stochastic model of aging in which the major premise is that the machinery involved in transcription, editing, and translation becomes less efficient over the life of an organism, and eventually reaches subvital activity levels. The assertion that aging occurs because of accumulated errors during protein synthesis that increase over the life of an organism was first proposed by American biologist Leslie Orgel (1927-); Aka error theory. As originally proposed, the theory lost influence, but a modern molecular reformulation has revived research interest.

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