Dictionary of Human Evolution and Biology

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Fetal Hemoglobin, Hereditary Persistence, Heterocellular

Abnormally high concentrations of circulating fetal hemoglobin (HbF) in an adult. Although all normal adults possess a small proportion of HbF, some individuals of African ancestry have higher levels of HbF. The condition has also been found in Greeks carrying either the beta-thalassemia or sickle cell allele, and is probably an additional mode of adaptation to malaria, since individuals with adult HbS would be at less risk for a sickling crisis in the presence of HbF. Heterocellular HPFH is an autosomal dominant gene. There is a second form, pancellular HPFH, also an autosomal dominant.

See hydroxyurea.

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