Dictionary of Human Evolution and Biology

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Elevation of body temperature above normothermia; pyrexia, usually accompanied by increase in pulse rate, restlessness, delirium, and possibly tissue destruction. The anterior hypothalamus is the suspected site of a normal febrile response to either an internal (endogenous) or an external (exogenous) pyrogen. A specific hypothalamic prostaglandin (E2) initiates the process, which is executed by hormones of the thyroid gland.

See hyperthermia.

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