Dictionary of Human Evolution and Biology

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Fructose Intolerance, Hereditary, Type I

Inability to metabolize fructose. Symptoms include hypoglycemia, sweating, nausea, tremors after ingesting fruit sugar, liver and kidney damage, and failure to thrive; fatal if untreated. Defective enzyme is fructose-1-phosphate aldolase (aldolase B, ALDOB, an autosomal recessive). About a dozen allelic mutations are known. Aka ALDOB deficiency. One of two types of fructose intolerance with a genetic basis.

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