Dictionary of Human Evolution and Biology

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Immunological Theory Of Aging

Intercellular, systemic model of aging in which the major premise is that cell recognition mechanisms begin to fail as an organism ages, resulting in failure of feedback mechanisms, or even, in some cases, autoimmunity, as originally proposed in 1969 by American pathologist Roy Walford (1924-2004). Certain haplotypes of the HLA complex seem to be associated with rates of aging, and are also factors in degenerative diseases, such as rheumatoid arthritis.

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