Dictionary of Human Evolution and Biology

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Inflammatory Bowel Disease I (IBD1)

One of a group of chronic autoimmune disorders that cause ulceration in the intestines. In type 1 (which includes Crohn disease) the inflammation extends deep into the intestinal wall. Onset is generally between 15 and 35 years of age, with a second peak in decades 5-7. About 1 in 5 cases of IBD1 are familial; prevalence is greater than 1: 1,000. Several autosomal recessive genes appear to be involved in the inflammatory response (including the NOD2 gene on chromosome 16q12), but the condition is generally regarded as heterogenous. A less severe form of IBD, type 2, is usually called ulcerative colitis. Females appear to be at an slightly increased risk for IBD.

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