Dictionary of Human Evolution and Biology

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Multigene Family

Set of genes generated by duplication and modified by selection on mutations to produce dissimilar but often related functions, and with striking sequence homology. Such genes may be scattered throughout a genome, or linked on a single chromosome, especially if produced by sequential endoreduplication. Examples of such families include the genes that code for the collagens, hemoglobins, histocompatibility anti-gens, histones, immunoglobulins, and keratins.

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