Dictionary of Human Evolution and Biology

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Any one of a small set of accelerated aging disorders. Progerias include Werner syndrome and Hutchinson-Gilford H-G syndrome (the latter is aka progeria proper). In H-G progeria, children usually die of a heart attack before the age of twelve. There are indications of a paternal age effect. Cells from affected individuals display a reduced number of replicative passages and a reduced ability to repair DNA. Recent evidence also suggests an autosomal recessive mode of inheritance.

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