Dictionary of Human Evolution and Biology

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Somatic Gene Therapy

Nonheritable modification of somatic cell genomes to cure or pre-vent deleterious conditions, without simultaneous modification of gametes or the germ-line. Typically, body cells are removed from an individual, genetically modified or engineered, and replaced again within the soma of the same individual; the result is an altered function or clinical result. Aka nonheritable somatic cell gene therapy.

See substitutional gene therapy and gametic gene therapy.

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