Dictionary of Human Evolution and Biology

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Somatostatin

1. any of several cyclic tetradecapeptides elaborated primarily by the median eminence of the hypothalamus and by the delta cells of the pancreas. The somatostatins inhibit release of growth hormone, thyrotropin, and corticotropin by the adenohypophysis, of insulin and glucagon by the pancreas, of gastrin by the gastric mucosa, of secretin by the intestinal mucosa, and of renin by the kidney. Aka growth hormone release-inhibiting hormone, somatotropin release-inhibiting hormone.

See insulin-like growth factor I.

2. a recombinant (genetically engineered) gene product. SS was spliced into the plasmid of E. coli in 1977, and became the first commercially produced human protein, followed shortly by insulin.

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