Dictionary of Human Evolution and Biology

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Systemic Lupus Erythematosus

Connective tissue disorder characterized by facial rash, the destruction of heart, brain and kidney cells, and a persistent high fever. One of the autoimmune diseases in which antibodies are produced against one’s own conservative elements in DNA, neurons and blood cells. HLA haplotypes containing the HLA DR3 antigen predispose individuals to this condition.

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From "Dictionary of Nursing and Individual Health Care"