Dictionary of Human Evolution and Biology

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Trinucleotide Expansion Disorder

Any condition characterized by a heritable trinucleotide repeat mutation in which a DNA triplet, that normally repeats only about 10-30 times, expands beyond the range of normal variation (60-3000 times). The numbers of expansions apparently increases with each generation and the severity of symptoms increase proportionately. Examples are Fragile X syndrome, Huntington disease, and myotonic dystrophy.

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