Dictionary of Human Evolution and Biology

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Trisomy 22

Major chromosome anomaly. Very rare condition in humans. There has been some confusion with trisomy 21. Affected individuals have large ears and nose, a small jaw, and a narrow face. Trisomy 22 in great apes results in 49 chromosomes instead of the normal 48, but the characteristic facies of Down syndrome in chimpanzees is clearly homologous with the human syndrome.

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