Dictionary of Human Evolution and Biology

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Xeroderma Pigmentosum

Autosomal recessive set of conditions (XPA, XPB,..., XPG) caused by deficient genes that are normally involved in DNA excision repair (cut-and-patch repair). XP is characterized by extreme sensitivity to UV radiation that results in unrepaired damage to fibroblast DNA and the formation of multiple pigmented spots that often become skin cancer. Onset in the first decade of life. Rare.

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